Entitled "Development and Characterization of Multifunctional Liposomal Formulations Based on Fungal Extracts for the Delivery of Bioactive Compounds with Applications in the Food and Cosmetics Industries," this initiative aims to optimize the delivery of bioactive compounds from adaptogenic fungi, maximizing their effectiveness and versatility.
The project addresses the growing demand for natural alternatives in health and wellness by combining biotechnological innovation with sustainability. This initiative aims not only to improve the absorption of bioactive compounds but also to reduce environmental impact through the use of agro-industrial waste.
What makes this proposal special?
The project is based on the creation of liposomes, small lipid vesicles capable of efficiently encapsulating and delivering bioactive compounds. This technology not only increases the bioavailability of the active ingredients but also overcomes one of the main limitations of traditional hydroalcoholic extracts: the presence of alcohol. Thanks to this innovation, it will be possible to create formulations suitable for children, animals, and people with health restrictions.
Furthermore, the proposal aligns with sustainability principles. Efforts will be made to optimize the industry’s resources, with a focus on producing lecithin from byproducts. This strategy offers a twofold benefit: on the one hand, it drives the development of more accessible and effective natural products; on the other, it promotes the circular economy and the recovery of waste.
The cornerstones of the project
To achieve its objective, the project is divided into three main phases:
Development and production of liposomes
- Development of protocols for the production of liposomes using soybean and/or sunflower lecithin.
Characterization of fungal extracts
- Evaluation of the antioxidant and anti-inflammatory properties of the extracts, both individually and in combination.
- Identification of key biomolecules to identify the extracts with the greatest bioactive potential.
Evaluation of the incorporation of the extracts into liposomes
- Incorporation of fungal extracts into liposomes, with tracking of selected biomolecules.
- Analysis of the stability of the formulations and evaluation of their antioxidant and anti-inflammatory properties.
The Power of Adaptogenic Mushrooms
Interest in bioactive compounds derived from mushrooms has grown exponentially in recent years, driven by their numerous health benefits. Adaptogenic mushrooms have stood out for their ability to strengthen the body’s resistance to stress, as well as for their anticancer, antidiabetic, antimicrobial, immunomodulatory, and antioxidant properties. These benefits have led to a surge in demand for products that include them in their formulation.
However, taking these extracts is not always easy. Hydroalcoholic extracts, while effective, have usage restrictions for certain groups of people. This is where liposome technology becomes a revolutionary solution. These delivery systems allow bioactive compounds to be encapsulated, facilitating their absorption and expanding their potential for use in topical or oral applications.
Expected impact
The approval of funding from ANII marks a milestone for research and innovation in Uruguay. The collaboration between academia and the company Mushlove will enable the generation of cutting-edge scientific knowledge with clear market applications.
The results of this research will not only boost the competitiveness of the domestic food and cosmetics industry, but will also position Uruguay as a leader in the development of technologies based on natural and sustainable bioactive compounds.
Through this collaboration, Dr. Mariana Umpiérrez and her team aim to contribute to holistic health, sustainability, and technological innovation.